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50+ Acre IH-10 Development Opportunity Between San Antonio & Seguin. Positioned in one of the region's fastest-growing corridors, this 50.32-acre tract offers outstanding visibility and accessibility with approximately 2,965 feet of road frontage and convenient access from an IH-10 off-ramp, creating strong potential for both regional and local traffic capture. With its size, frontage, and strategic location, the property is well suited for a wide range of commercial, residential, and mixed-use development possibilities. Potential uses may include a truck stop or travel center, fuel station, quick-service restaurants, strip center, retail pad sites, multifamily, build-to-rent housing, single-family residential development, flex/industrial space, contractor services, storage, hospitality, or other high-demand commercial uses serving the continued growth between San Antonio, New Braunfels, Seguin, and surrounding communities. Large tracts with this level of interstate exposure and access are increasingly difficult to find. Whether held for investment, developed in phases, or positioned for a larger master-planned concept, this property offers the visibility, scale, and location needed for a standout project along the IH-10 corridor. Buyer to verify zoning, utilities, permitted uses, access, and development requirements.

Highlights

  • Commercial Sale
  • Unimproved Land
  • 50.32 Acre Lot
  • 131 days on Market


  • Acres
    50.32
  • Lot Features
    Level
  • Utilities
    Electricity Available

  • County
    Guadalupe
  • City
    Marion
  • Zip Code
    78124

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Frequently Asked Questions

How do I schedule a tour of 10221 E Interstate Highway 10?

We can make that happen quickly. Click Tour This Home and we'll connect you directly with our vetted local partner to schedule your visit to 10221 E Interstate Highway 10.

They know commercial sales in the area well and can give you the guidance you need to buy with confidence.

How do I get more information about 10221 E Interstate Highway 10?

Click Ask a Question to talk with our team. You already know it is a N/A bed, N/A bath, listed for $5,032,000. We can talk through recent upgrades, potential seller motivation, how this unimproved land compares to others in Marion, and can even get you in to see the property quickly.

How do I get a virtual tour of 10221 E Interstate Highway 10?

Yes! A virtual tour is available for 10221 E Interstate Highway 10. Click here to view the full walkthrough and explore every room at your own pace. If you would like a guided virtual showing or have questions along the way, we can connect you with our local expert to walk you through it live.

How much is the monthly mortgage payment for 10221 E Interstate Highway 10?

With a 20% down payment and a 30-year fixed loan at an illustrative 7.25% rate, the ez Mortgage Calculator estimates the monthly payment for 10221 E Interstate Highway 10 at around $30,282. This includes estimated property taxes and insurance.

Want to see how this changes with different down payments or interest rates? Jump to the calculator to run the numbers and fine-tune your plan.

How do I get pre-approved to buy 10221 E Interstate Highway 10?

Stand out in a competitive market by getting pre-approved today. Our quick and private pre-approval process helps you understand your true buying power—no credit pull required to explore all of your options.

Or, let us connect you with our preferred local lender in Guadalupe County. They will give you all of your available financing options, based on your specific situation and what is available to you.

Can I negotiate the asking price for 10221 E Interstate Highway 10?

In most cases, yes. Whether 10221 E Interstate Highway 10 is priced competitively or not, your best offer depends on your personal situation, the seller's timeline, and recent activity in Marion's market. Our preferred local partner will help you craft a strategy—factoring in comparable properties that have sold, timing, and deal structure—to make a smart, strong offer. Click here to ask about negotiation opportunities.

How do I make an offer on 10221 E Interstate Highway 10?

We can handle that for you. Our preferred local agent specializes in commercial sales in Marion and can guide you through every step of the offer process.

You need an expert who is looking out for your best interests. From market valuation to contingencies and timing, they'll help you present a compelling offer that fits your goals. Click Ask a Question to get started today.

How long has this property been on the market?

10221 E Interstate Highway 10 was listed on June 30, 2026, which means it's been on the market for 131 days.

Want to keep tabs on it? Click the ♥ to favorite this home and get notified of price drops or changes.

What is the lot size of this property?

10221 E Interstate Highway 10 sits on a 50.32-acre lot, which is 2,191,939 square feet.

What are the property taxes for 10221 E Interstate Highway 10?

The most recent public record shows annual property taxes for 10221 E Interstate Highway 10 were approximately $19,760. This may change with reassessment or exemptions. Our local partner can verify current tax amounts and help you estimate future costs based on your situation.

Is 10221 E Interstate Highway 10 still available for sale?

Yes, this home is still available! Click the ♥ to favorite it so you don't miss any changes—or ask our local expert to schedule a time to see it in person.

Source: ez Home Search, MLS Data

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Listing information provided exclusively for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Information deemed reliable but not guaranteed by the MLS. The listing broker’s offer of compensation is made only to participants of the MLS where the listing is filed. Copyright 2026, San Antonio Board of REALTORS. All rights reserved.

Last Updated: November 08, 2026 at 06:00PM | Source: San Antonio Board of REALTORS | MLS#: 1996188