Searching ...

Historic Redevelopment Opportunity – O'Neill Block | Dubuque, Iowa The O'Neill Block presents a rare 18,288 SF mixed-use redevelopment opportunity in the heart of Dubuque’s Old Main Historic District. Seller will consider flexible financing options, including a potential land contract, for qualified buyers. The property features two commercial spaces on the main floor, including a 4,062 SF restaurant/bar with a 6,092 SF finished lower-level bar previously operating as 1st & Main, along with a 2,031 SF bar/retail space formerly known as Esther’s Lounge (spaces are part of the sale but could also be leased). Site also offers a 1,428 SF outdoor patio. These spaces could continue as hospitality venues or be converted into office, retail, or other commercial uses. The upper two floors offer more than 12,000 SF of redevelopment potential, ideal for apartments, condominiums, boutique offices, or creative workspaces, providing a true blank slate for a transformative mixed-use project. Located within the Dubuque Opportunity Zone, the property may qualify for Historic Tax Credits, Tax Increment Financing (TIF), and City of Dubuque housing and façade incentives. The building sits in the center of major downtown investment, including the new John and Alice Butler College of Osteopathic Medicine developed by the University of Dubuque, expansion of the Dubuque Museum of Art, and continued redevelopment in the Historic Millwork District. This site is in extremely close proximity to the Five Flags Center and nearby hotels including Hotel Julien Dubuque and Holiday Inn Dubuque/Galena, the location benefits from strong tourism, event traffic, and a growing downtown residential base. Positioned just one block from the Highway 20 / 61 / 151 corridor, the O’Neill Block offers outstanding visibility and access, making it one of the most compelling historic redevelopment opportunities in downtown Dubuque. Drone video: https://youtu.be/Acx-GA4lhEo?si=7d8fRO-6uFQgwHwh

Highlights

  • Commercial Sale
  • Industrial
  • Built in 1900
  • 35 days on Market

  • Year Built
    1900
  • Stories
    3.0
  • Construction Materials
    Brick
  • Foundation
    Stone
  • Flooring
    Concrete, Wood
  • Cooling
    Central Air
  • Heating
    Forced Air, Natural Gas
  • Basement
    Full

  • Utilities
    Natural Gas Available
  • Water
    Public


Ask a Question

What's your home worth?

Calculate your current home value within seconds.

Frequently Asked Questions

How do I schedule a tour of 101 Main St?

We can make that happen quickly. Click Tour This Home and we'll connect you directly with our vetted local partner to schedule your visit to 101 Main St.

They know commercial sales in the area well and can give you the guidance you need to buy with confidence.

How do I get more information about 101 Main St?

Click Ask a Question to talk with our team. You already know it is a N/A bed, N/A bath, listed for $1,290,000. We can talk through recent upgrades, potential seller motivation, how this industrial compares to others in Dubuque, and can even get you in to see the property quickly.

How much is the monthly mortgage payment for 101 Main St?

With a 20% down payment and a 30-year fixed loan at an illustrative 7.25% rate, the ez Mortgage Calculator estimates the monthly payment for 101 Main St at around $7,341. This includes estimated property taxes and insurance.

Want to see how this changes with different down payments or interest rates? Jump to the calculator to run the numbers and fine-tune your plan.

How do I get pre-approved to buy 101 Main St?

Stand out in a competitive market by getting pre-approved today. Our quick and private pre-approval process helps you understand your true buying power—no credit pull required to explore all of your options.

Or, let us connect you with our preferred local lender in Dubuque County. They will give you all of your available financing options, based on your specific situation and what is available to you.

Can I negotiate the asking price for 101 Main St?

In most cases, yes. Whether 101 Main St is priced competitively or not, your best offer depends on your personal situation, the seller's timeline, and recent activity in Dubuque's market. Our preferred local partner will help you craft a strategy—factoring in comparable properties that have sold, timing, and deal structure—to make a smart, strong offer. Click here to ask about negotiation opportunities.

How do I make an offer on 101 Main St?

We can handle that for you. Our preferred local agent specializes in commercial sales in Dubuque and can guide you through every step of the offer process.

You need an expert who is looking out for your best interests. From market valuation to contingencies and timing, they'll help you present a compelling offer that fits your goals. Click Ask a Question to get started today.

What is the price per square foot for this home?

This home is listed at $1,290,000 with 18,288 sqft of space—that comes out to approximately $71 per square foot.

How long has this property been on the market?

101 Main St was listed on October 05, 2026, which means it's been on the market for 35 days.

Want to keep tabs on it? Click the ♥ to favorite this home and get notified of price drops or changes.

When was this house built?

This home was built in 1900, making it approximately 126 years old.

Is 101 Main St still available for sale?

Yes, this home is still available! Click the ♥ to favorite it so you don't miss any changes—or ask our local expert to schedule a time to see it in person.

Source: ez Home Search, MLS Data

Popular Home Searches in Dubuque, IA


Search Nearby Cities


Search Nearby Postal Codes

The data relating to real estate for sale on this website comes in part from the Internet Data exchange (IDX) program of Dubuque Multiple Listing Service. IDX information is provided exclusively for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Information deemed reliable but not guaranteed. Copyright 2026 Dubuque Multiple Listing Service. All Rights Reserved.

Last Updated: November 09, 2026 at 11:04PM | Source: East Central Iowa Association of REALTORS | MLS#: 156129